Different studies in the last decades have shown the decrease of the sperm quality. We have believed that the paternal age did not play an important role in the positive outcome of an IVF cycle.

Τάνια 1

A recent publication from the Montpellier University Hospital in France shows that there is a significant paternal age effect of the sperm on both the blastocyst formation and pregnancy rates.

In total, 859 IVF and 1632 ICSI cycles accumulated over a 5year period were included in this study. Exclusion criteria were cycles using frozen sperm, sperm from TESE and frozen oocytes. The research shows that oligospermia has a reduced fertilization rate after ICSI and a reduced blastulation rate. The effect of Paternal age on pregnancy rates appeared when father was older than 51 years of age and the mother older than 37 years.

In conclusion, in the case of severe oligospermia, transfer should be carried out at the cleaved embryo stage (day2-3) due to the very low blastulation rate. When the man is older than 51 years old and the woman over the 37 years of age, couples should be aware of the reduced success rates.

Source: Basic Clin Androl. 2017 Jan 21;27:2


Karagianni Tania M.Sc

Clinical Embryologist