Thrombophilia is defined as an acquired or inherited disorder associated with the thrombosis of blood in the vessels. The clinical manifestation of thrombophilia may involve serious disorders during pregnancy or repeated miscarriages for pregnant women.

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Specifically, during the embryo conception and during the period of its adhesion to the uterus, its blood supply depends on the maternal circulation. Factors that increase the risk for thrombophilia episodes among people with thrombophilia are: the advanced age, obesity, contraceptive use. The tendency of the formation of thrombus can be inherited to the person from one or both parents through their genes (hereditary) or can be due to various acquired conditions or circumstances (acquired thrombophilia).

Past and recent studies have shown that there is a correlation between maternal thrombophilia and the loss of the fetus on the 10th or 20th week of pregnancy, as well as the unsuccessful attempts of normal conception or after IVF.

Consequently, it is recommended that women with a history of thrombosis or women who have first-degree relatives with a history of thrombophilia should undergo a series of blood tests for both hereditary and acquired thrombophilia.Women with any positive result should be referred to a specialist haematologist.

Advice should include changes in diet, the way of life, special care before using contraceptive. Thrombophilia is more common in women than in men. Therefore, the presence of thrombophilic factors in pregnancy may be common, but their complications can be prevented with proper monitoring and the right treatment.

More data will be given by Mr. Karamalegkos Christos, Head of Haematology Tests and Research at Embryogenesis, who will analyze the relationship between genetic thromvrofilia and infertility / miscarriage with Embryogenesis' rates.

 

Argyrou Marina, PhD

Clinical Embryologist, Embryogenesis