Different Stimulation Protocols

Your Clinician will recommend the most appropriate protocol for you, considering the history, the age, the ovarian response in previous attempts etc.  In recent years, both us at Embryogenesis and internationally, have largely adopted the short protocol with the antagonist which is very friendly and equally effective as the long one. Its duration is only 10 to 12 days with much fewer injections.

  • The Short Protocol

In the short protocol, the beginning takes place necessarily on the 1st day of the cycle and either an analog may be used (Suprefact / Daronda / Arvekap) or an antagonist (Cetrotide, Orgalutran). Before starting the short protocol a vaginal ultrasound is taking place so as to rule

  • The Long Protocol

In the long protocol the start of the analog (Suprefact / Daronda / Arvekap) takes place at the 21st or the 1st day of the cycle. The first two weeks concern only the prescription of the analog while during the last two weeks the stimulating drug is being added (Gonal-F, Puregon, Altermon, Menogon, Menopur, Merional) without stopping the analog.

During this phase, an informal period can occur, which is expected, and therefore should not worry you at all. As a first day, we consider the appearance of little red blood (not the initial browny blood). You should never stop the "suppression" drugs (Suprefact / Daronda / Arvecap) as long as you started taking them, until the moment of the "midnight injection". 

 

Midnight injection

This injection (Pregnyl / Ovitrelle) is done for the final maturation of the oocytes. We call it this way, because it is done around midnight, and the oocyte retrieval can follow 36 hours later.

 

Pregnancy test

The pregnancy test (hCG measurement) should be done approximately 12 days after the embryo transfer day.

If the result is positive, we will plan a vaginal ultrasound two weeks later to see the developing embryo(s). The pregnancy after IVF does not differ from any other pregnancy following natural conception. It should be emphasized that any pregnancy either after IVF or after normal fertilization is unfortunately subjected to a miscarriage risk, which may be up to 15-20%.

If the test is negative, we firmly believe that the responsible scientific team should review with you the attempt and examine in detail the prospects for the future.